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Caseinophosphopeptides cytoprotect human gastric epithelium cells against the injury induced by zinc oxide nanoparticles
文献类型:期刊论文
作者:Wang, Yanli[1]  Yuan, Lulu[2]  Yao, Chenjie[3]  Ding, Lin[4]  Li, Chenchen[5]  Fang, Jie[6]  Wu, Minghong[7]  
机构:[1]Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai, Peoples R China.;
[2]Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai, Peoples R China.;
[3]Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai, Peoples R China.;
[4]Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai, Peoples R China.;
[5]Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai, Peoples R China.;
[6]Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai, Peoples R China.;
[7]Shanghai Univ, Sch Environm & Chem Engn, Shanghai, Peoples R China.;
通讯作者:Wang, Yanli
年:2014
期刊名称:RSC ADVANCES影响因子和分区
卷:4
期:79
页码范围:42168-42174
增刊:正刊
收录情况:SCI(E)(WOS:000342161600061)  EI(20143900070544)  
所属部门:环境与化学工程学院
语言:外文
ISSN:2046-2069
被引频次:4
人气指数:155
浏览次数:155
基金:National Basic Research Program of China (973 Program) [2011CB933402]; National Natural Science Foundation of China [21101104, 21371115, 11025526]; Innovation Program of Shanghai Municipal Education Commission [14YZ025]; Program for Innovative Research Team in University [IRT13078]
摘要:
Zinc oxide nanoparticles (ZnO NPs) are widely used as food additives, especially in nutritional foods. However, many reports have demonstrated their toxicity in humans and other biological systems. Our study has confirmed that ZnO NPs can induce apoptosis and oxidative damage on human gastric epithelium cells (GES-1). Caseinophosphopeptides (CPP) are also used as functional food additives that sequester prooxidant metals and scavenge free radicals. Herein, we investigate the combined cytotoxicit ...More
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